CSTD (Closed System Transfer Devices)

CSTD Manufacturers and Efficacy, Closed System Transfer Device Comparisons and Studies, CSTD and USP 800 Regulations, Leur-Lock Compatibility and Assembly, Chemotherapy / Hazardous Drugs, NIOSH...

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7-Minute Video | CSTD perspectives from 5 industry thought leaders.

7-Minute Video | CSTD perspectives from 5 industry thought leaders.

RXinsider

CSTD perspectives from five industry thought leaders: Discussions with DJ Semenza (EQUASHIELD), Ryan Forrey (BD), Allison Burcar (ICU Medical), Andrew Tavares (B. Braun Medical), and Jared Garfield (Corvida Medical). These industry experts answer the following questions: What are CSTDs? Why do pharmacists and nurses use CSTDs? How do CSTDs help protect healthcare professionals form hazardous drugs? What factors should be considered when choosing a particular CSTD?

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CSTD (Closed System Transfer Devices)

A closed system drug transfer device or "CSTD" is a drug transfer device that mechanically prohibits the transfer of environmental contaminants into a system and the escape of hazardous drug or vapor concentrations outside the system. Open versus closed systems are commonly applied in medical devices to maintain the sterility of a fluid pathway. CSTDs work by preventing the uncontrolled inflow and outflow of contaminants and drugs, preserving the quality of solution to be infused into a patient. Theoretically, CSTDs should enable complete protection to healthcare workers in managing hazardous drugs, but possibly due to improper handling or incomplete product design, contaminants can still be detected despite use of CSTDs.

Source: Miyake, Tomohiro; Iwamoto, Takuya; Tanimura, Manabu; Okuda, Masahiro (2013-06-21). "Impact of closed-system drug transfer device on exposure of environment and healthcare provider to cyclophosphamide in Japanese hospital". SpringerPlus. 2. doi:10.1186/2193-1801-2-273. ISSN 2193-1801. PMC 3698436. PMID 23853750.

A Performance Test Protocol for Closed System Transfer Devices Used During Pharmacy Compounding and
A 44-page document that describes, in detail, the NIOSH testing protocols used for CSTDs. This document details which compounds were tested, what the conditions were, which CSTDs were tested, specifics on how they were tested. This document reads very similarly to a student lab report.
Arisure CSTD by Yukon Medical
Arisure manufacturer website that describes the newest CSTD to enter the market. Website describes some features that are exclusive to the Arisure, as well as separate sets of specific reasons why this product is appealing to nurses and pharmacists.
ChemoLock CSTD by ICU Medical
ChemoLock CSTD manufacturer website that describes all of the features of this device, especially focusing on its ease of use and safety for healthcare workers. This site also illustrates all of the available components.
Chemotherapy Drugs in a Clinical Setting
This study's aim was to determine how HD might spread through touch after handling contaminated vials in simulated pharmacy and nursing environments. Results show residue from HD vials spread as vial was handled in a pharmacy environment in 4 of 5 CSTDs, contaminating pharmacy PPE, ancillary products, and nursing PPE. No HD residue was detected on PPE, ancillary products, or nursing PPE in the pharmacy after using the SEVA system, providing an effective means to contain HD for drug transfer from vial to delivery system. Call E, Bill B, McLean C, Call N, Bernkopf A, Oberg C. Hazardous Drug Contamination of Drug Preparation Devices and Staff: A Contamination Study Simulating the Use of Chemotherapy Drugs in a Clinical Setting. Hosp Pharm. 2017;52(8):551-558.
Comparison of closed system transfer devices for turnaround time and ease of use. J Oncol Pharm Prac
A Saudi Arabian study, published in May 2018, that sought to compare 3 CSTD’s (PhaSeal, Equashield II and ChemoLock) on their compounding efficiency and ease of use among pharmacy technicians and nurses to determine which product would be most suitable to adopt into their hospital protocol. Nurgat ZA, Lawrence M, Elhassan TA, et al. Comparison of closed system transfer devices for turnaround time and ease of use. J Oncol Pharm Practice. 2018;0(0):1-10.
Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineop
The objective of this randomized, prospective and controlled study was to investigate the ability of a closed-system transfer device (CSTD; BD-Phaseal) to reduce the occupational exposure of two isolators to 10 cytotoxic drugs and compare to standard compounding devices. This study confirms that using a CSTD may significantly decrease the chemical contamination of barrier isolators compared to standard devices for some drugs, although it does not eliminate contamination totally.Simon N, Vasseur M, Pinturaud M, et al. Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study. PLoS One. 2016;11(7).
Equashield II CSTD by Equashield
Equashield device manufacturer website that illustrates the Equashield device and describes all of its available features. It also describes why CSTDs are necessary in the hospital and what exactly they do. It specifically details how the Equashield is better and different from the other marketable CSTDs.
Multicenter evaluation of a new closed system drug-transfer device in reducing surface contamination
Rigorous protocol study at 13 cancer centers across the United States on the effectiveness of the Halo in reducing surface contamination when compounding and simulated administering antineoplastic drugs, cyclophosphamide and fluorouracil. The Halo was found to effectively reduce surface contamination by cyclophosphamide and fluorouracil, and was also found to be easy to use by healthcare workers. Bartel SB, Tyler TG, Power LA. Multicenter evaluation of a new closed system drug-transfer device in reducing surface contamination by antineoplastic hazardous drugs. American Journal of Health-System Pharmacy. 2018;75(4):199-211. doi:10.2146/ajhp160948
OnGuard CSTD by B. Braun Medical
OnGuard device manufacturer website that describes the OnGuard product and addresses the need for this device in the hospital in light of the upcoming, enforceable .
PhaSeal CSTD by BD
PhaSeal manufacturer website that describes the different components of the PhaSeal device. It details how this CSTD works for drug preparation, drug transport, IV administration and disposal. It also includes a mini-quiz that tests how knowledgeable you are about .



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